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    Silence Therapeutics plc (SLN)

    Price:

    6.44 USD

    ( + 0.18 USD)

    Your position:

    0 USD

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    Symbol
    SLN
    Name
    Silence Therapeutics plc
    Industry
    Biotechnology
    Sector
    Healthcare
    Price
    6.440
    Market Cap
    304.187M
    Enterprise value
    203.693M
    Currency
    USD
    Ceo
    Craig A. Tooman
    Full Time Employees
    116
    Ipo Date
    2020-09-08
    City
    London
    Address
    72 Hammersmith Road

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    SIMILAR COMPANIES STI SCORE

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    Market Cap
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    Industry
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    Industry
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    The best

    Genmab A/S

    VALUE SCORE:

    11

    Symbol
    GMAB
    Market Cap
    126.546B
    Industry
    Biotechnology
    Sector
    Healthcare
    FUNDAMENTALS
    P/E
    -1.745
    P/S
    12.260
    P/B
    -1.350
    Debt/Equity
    0.002
    EV/FCF
    -3.175
    Price to operating cash flow
    -1.000
    Price to free cash flow
    -1.000
    EV/sales
    8.946
    Earnings yield
    -0.573
    Debt/assets
    -0.001
    FUNDAMENTALS
    Net debt/ebidta
    1.178
    Interest coverage
    6.493
    Research And Developement To Revenue
    3.200
    Intangile to total assets
    0.074
    Capex to operating cash flow
    -0.001
    Capex to revenue
    0.002
    Capex to depreciation
    0.468
    Return on tangible assets
    -0.422
    Debt to market cap
    -0.001
    Piotroski Score
    5.000
    FUNDAMENTALS
    PEG
    0.060
    P/CF
    -1.431
    P/FCF
    -4.351
    RoA %
    -39.031
    RoIC %
    -69.593
    Gross Profit Margin %
    92.873
    Quick Ratio
    7.689
    Current Ratio
    7.689
    Net Profit Margin %
    -230.909
    Net-Net
    12.339
    FUNDAMENTALS PER SHARE
    FCF per share
    -4.503
    Revenue per share
    1.598
    Net income per share
    -3.691
    Operating cash flow per share
    -4.499
    Free cash flow per share
    -4.503
    Cash per share
    6.583
    Book value per share
    14.140
    Tangible book value per share
    13.437
    Shareholders equity per share
    -4.771
    Interest debt per share
    -0.755
    TECHNICAL
    52 weeks high
    8.080
    52 weeks low
    1.970
    Current trading session High
    6.600
    Current trading session Low
    6.220
    DIVIDEND
    Dividend yield
    0.00%
    Payout ratio
    0.00%
    Years of div. Increase
    0
    Years of div.
    0
    Q-shift
    Dividend per share
    0
    SIMILAR COMPANIES
    logo

    Country
    CH
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -5.064
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -5.463
    logo

    Country
    IE
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -69.913
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -6.039
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -18.255
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -6.240
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -2.276
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -3.788
    logo

    Country
    US
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -1.873
    logo

    Country
    GB
    Sector
    Healthcare
    Industry
    Biotechnology
    Dividend yield
    0%
    Payout Ratio
    0%
    P/E
    -7.309
    DESCRIPTION

    Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.

    NEWS
    https://images.financialmodelingprep.com/news/silence-therapeutics-divesiran-targets-highburden-pv-20251118.jpg
    Silence Therapeutics: Divesiran Targets High-Burden PV

    seekingalpha.com

    2025-11-18 06:03:40

    Silence Therapeutics is advancing its lead RNAi drug, divesiran, for polycythemia vera, with a fully enrolled Phase 2 trial and results expected in Q3 2026. SLN boasts a strong cash position ($100M+), providing runway through 2028 and enabling continued pipeline development without near-term financing risks. The SANRECO trial's design and patient population position divesiran as a potential adjunctive therapy for high-burden PV patients, focusing on reduced phlebotomy frequency and infrequent dosing.

    https://images.financialmodelingprep.com/news/silence-therapeutics-reports-third-quarter-2025-financial-results-and-20251106.jpg
    Silence Therapeutics Reports Third Quarter 2025 Financial Results and Recent Business Highlights

    businesswire.com

    2025-11-06 07:30:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported its financial results for the third quarter ended September 30, 2025, and reviewed recent business highlights. “Silence continues to focus on operational execution, highlighted by the rapid achievement of full enrollment in our ongoing SANRECO Phase 2 study of divesiran, our first-in-class siRNA for.

    https://images.financialmodelingprep.com/news/tonix-pharmaceuticals-nasdaqtnxp-versus-silence-therapeutics-nasdaqsln-critical-survey-20251031.png
    Tonix Pharmaceuticals (NASDAQ:TNXP) versus Silence Therapeutics (NASDAQ:SLN) Critical Survey

    defenseworld.net

    2025-10-31 01:40:53

    Silence Therapeutics (NASDAQ: SLN - Get Free Report) and Tonix Pharmaceuticals (NASDAQ: TNXP - Get Free Report) are both medical companies, but which is the superior business? We will contrast the two companies based on the strength of their earnings, risk, analyst recommendations, dividends, institutional ownership, valuation and profitability. Institutional and Insider Ownership 98.7% of Silence Therapeutics

    https://images.financialmodelingprep.com/news/silence-therapeutics-completes-enrollment-in-sanreco-phase-2-study-20251023.jpg
    Silence Therapeutics Completes Enrollment in SANRECO Phase 2 Study of Divesiran for Polycythemia Vera (PV)

    businesswire.com

    2025-10-23 07:30:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced it has completed patient enrollment in the SANRECO Phase 2 study of divesiran, a first-in-class siRNA targeting TMPRSS6, for the treatment of polycythemia vera (PV). Initial topline results from the SANRECO Phase 2 study are anticipated in the third quarter of 2026. SANRECO is a global, randomized, double-blind, placebo-contro.

    https://images.financialmodelingprep.com/news/silence-therapeutics-plc-sln-presents-at-morgan-stanley-23rd-annual-20250909.jpg
    Silence Therapeutics Plc (SLN) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference Transcript

    seekingalpha.com

    2025-09-09 22:01:21

    Silence Therapeutics plc (NASDAQ:SLN ) Morgan Stanley 23rd Annual Global Healthcare Conference September 9, 2025 5:35 PM EDT Company Participants Michael Ulz - Equity Analyst Craig Tooman - President, CEO & Executive Director Steven Romano - Executive VP and Chief Research & Development Officer Presentation Michael Ulz Equity Analyst All right. Good afternoon, everyone, and thanks for joining us at the Morgan Stanley Global Healthcare Conference.

    https://images.financialmodelingprep.com/news/silence-therapeutics-reports-second-quarter-2025-financial-results-and-20250807.jpg
    Silence Therapeutics Reports Second Quarter 2025 Financial Results and Recent Business Highlights

    businesswire.com

    2025-08-07 07:30:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported its financial results for the second quarter ended June 30, 2025, and reviewed recent business highlights. “The updated data we presented at EHA this past quarter were highly encouraging and supportive of the therapeutic potential of divesiran as a first-in-class siRNA in PV,” said Craig Tooman, Pres.

    https://images.financialmodelingprep.com/news/silence-therapeutics-presents-additional-phase-1-data-highlighting-promise-20250612.jpg
    Silence Therapeutics Presents Additional Phase 1 Data Highlighting Promise of Divesiran as the Potential First-in-Class siRNA Treatment for Polycythemia Vera

    businesswire.com

    2025-06-12 16:01:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc (“Silence” or the “Company”) (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today presented additional data showcasing the SANRECO Phase 1 study of divesiran in patients with polycythemia vera (PV) at the European Hematology Association (EHA) 2025 Annual Meeting in Milan, Italy. “The latest data presented at EHA today continue to demonstrate divesiran's potential to maintain rapid and dur.

    https://images.financialmodelingprep.com/news/wall-street-analysts-think-silence-therapeutics-sln-could-surge-55619-20250606.jpg
    Wall Street Analysts Think Silence Therapeutics (SLN) Could Surge 556.19%: Read This Before Placing a Bet

    zacks.com

    2025-06-06 10:56:12

    The consensus price target hints at a 556.2% upside potential for Silence Therapeutics (SLN). While empirical research shows that this sought-after metric is hardly effective, an upward trend in earnings estimate revisions could mean that the stock will witness an upside in the near term.

    https://images.financialmodelingprep.com/news/wall-street-analysts-believe-silence-therapeutics-sln-could-rally-20250521.jpg
    Wall Street Analysts Believe Silence Therapeutics (SLN) Could Rally 590.66%: Here's is How to Trade

    zacks.com

    2025-05-21 11:01:25

    The mean of analysts' price targets for Silence Therapeutics (SLN) points to a 590.7% upside in the stock. While this highly sought-after metric has not proven reasonably effective, strong agreement among analysts in raising earnings estimates does indicate an upside in the stock.

    https://images.financialmodelingprep.com/news/silence-therapeutics-reports-first-quarter-2025-financial-results-and-20250508.jpg
    Silence Therapeutics Reports First Quarter 2025 Financial Results and Recent Business Highlights

    businesswire.com

    2025-05-08 08:00:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported its financial results for the first quarter ended March 31, 2025, and reviewed recent business highlights. “Silence delivered another strong quarter focused on clinical and operational execution,” said Craig Tooman, President and Chief Executive Officer at Silence. “We remain focused on advancing enr.

    https://images.financialmodelingprep.com/news/silence-therapeutics-welcomes-tim-mcinerney-to-board-of-directors-20250506.jpg
    Silence Therapeutics Welcomes Tim McInerney to Board of Directors

    businesswire.com

    2025-05-06 07:45:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced the appointment of Tim McInerney to the Company's Board of Directors, effective immediately. Mr. McInerney will stand for re-appointment to the Silence Board at the Annual General Meeting (“AGM”) in June 2025. “We are thrilled to welcome Tim to the Silence Board,” said Iain Ross, Chairman of the Sil.

    https://images.financialmodelingprep.com/news/silence-therapeutics-to-webcast-presentation-at-the-leerink-partners-20250305.jpg
    Silence Therapeutics to Webcast Presentation at the Leerink Partners Global Healthcare Conference

    businesswire.com

    2025-03-05 08:00:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or the “Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced that management will present a company overview at the Leerink Partners Global Healthcare Conference on Wednesday, March 12th at 1:00 p.m. ET. The live webcast can be accessed via the Investors section of the Silence website at www.silence-therapeutics.com. An archived replay of the webcast will be.

    https://images.financialmodelingprep.com/news/silence-therapeutics-sln-upgraded-to-buy-heres-what-you-20250304.jpg
    Silence Therapeutics (SLN) Upgraded to Buy: Here's What You Should Know

    zacks.com

    2025-03-04 13:05:32

    Silence Therapeutics (SLN) has been upgraded to a Zacks Rank #2 (Buy), reflecting growing optimism about the company's earnings prospects. This might drive the stock higher in the near term.

    https://images.financialmodelingprep.com/news/silence-therapeutics-plc-sln-q4-2024-earnings-call-transcript-20250228.jpg
    Silence Therapeutics plc (SLN) Q4 2024 Earnings Call Transcript

    seekingalpha.com

    2025-02-28 11:59:32

    Silence Therapeutics plc (NASDAQ:SLN ) Q4 2024 Earnings Call February 27, 2025 8:00 AM ET Company Participants Gem Hopkins - Vice President, Investor Relations and Corporate Communications Craig Tooman - President and Chief Executive Officer Rhonda Hellums - Chief Financial Officer Steven Romano - Chief R&D Officer Conference Call Participants Mike Ulz - Morgan Stanley Kostas Biliouris - BMO Capital Markets Richard Law - Goldman Sachs Keay Nakae - Chardan Myles Minter - William Blair Gem Hopkins Good morning and good afternoon, everyone. Thank you for joining us today.

    https://images.financialmodelingprep.com/news/silence-therapeutics-reports-full-year-2024-financial-results-and-20250227.jpg
    Silence Therapeutics Reports Full Year 2024 Financial Results and Provides Business Update

    businesswire.com

    2025-02-27 07:30:00

    LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported its financial results for the full year ended December 31, 2024, and provided a business update. “2024 was marked by strong clinical execution and pipeline advancement, highlighting the broad potential of our mRNAi GOLD™ platform to silence disease causing genes,” said Craig Tooman, President and CEO.