Centessa Pharmaceuticals plc (CNTA)
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Centessa Pharmaceuticals plc, a clinical-stage pharmaceutical company, discovers, develops, and delivers medicines to patients. Its registrational pipeline products include Lixivaptan, a vasopressin V2 receptor small molecule inhibitor that is in Phase III clinical development for the treatment of autosomal dominant polycystic kidney disease; and SerpinPC, an activated protein C inhibitor, which is in Phase IIa clinical development for the treatment of hemophilia A and B. The company also has emerging pipeline products under clinical proof of concept stage comprising LB101, a PD-L1xCD47 LockBody, as well as LB201, a PD-L1xCD3 LockBody, which are designed to selectively drive potent CD47 and CD3 effector function activity while avoiding systemic toxicity; ZF874, a small molecule pharmacological chaperone folding corrector of the Z variant of alpha-1-antitrypsin in Phase I clinical development for the treatment of alpha-1-antitrypsin deficiency; MGX292, a recombinant modified BMP9 replacement protein designed to overcome the deficiency in BMP9 signaling in Pulmonary Arterial Hypertension; and OX2R Agonists that are oral and intranasal selective orexin receptor 2 agonists designed to leverage structural insights and to directly target the underlying pathophysiology of orexin neuron loss in Narcolepsy Type 1. In addition, the company has exploratory pipeline products under clinical proof of concept stage containing CBS001, an anti-LIGHT antibody, which preferentially binds the inflammatory membrane form of LIGHT in inflammatory/fibrotic diseases; and CBS004, a humanized mAb specific to BDCA2, expressed exclusively on plasmacytoid dendritic cells in systemic sclerosis, systemic lupus erythematosus, and other autoimmune diseases. Centessa Pharmaceuticals plc was incorporated in 2020 and is based in Altrincham, the United Kingdom.
NEWS

Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ:CNTA) Receives Consensus Recommendation of “Buy” from Analysts
defenseworld.net
2025-12-13 01:16:58Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ: CNTA - Get Free Report) has been assigned an average recommendation of "Buy" from the thirteen analysts that are currently covering the firm, MarketBeat Ratings reports. One equities research analyst has rated the stock with a sell rating, ten have assigned a buy rating and two have assigned a strong

Centessa Pharmaceuticals Announces CEO Transition as Company Advances Strategy to Extend Orexin Leadership into Multiple Neuroscience Indications
globenewswire.com
2025-12-11 07:00:00Mario Alberto Accardi PhD, President and founder of Centessa's Orexin Program, appointed Chief Executive Officer and member of the Board of Directors Mario Alberto Accardi PhD, President and founder of Centessa's Orexin Program, appointed Chief Executive Officer and member of the Board of Directors

What One Fund's Sale of Centessa Stock Signals About the Fast-Rising Biotech Company
fool.com
2025-11-29 13:48:38San Francisco-based 5AM Venture Management sold 150,000 CNTA shares in the third quarter. Despite the sale, the stock's sharp rally last quarter led the fund's net position value in CNTA to increase by $5.6 million.

Campbell & CO Investment Adviser LLC Acquires New Position in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA
defenseworld.net
2025-11-18 03:53:03Campbell and CO Investment Adviser LLC bought a new position in shares of Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ: CNTA) during the second quarter, according to its most recent filing with the Securities and Exchange Commission. The institutional investor bought 16,619 shares of the company's stock, valued at approximately $218,000. Other hedge funds

Centessa Stock Has Surged 77% Over the Past Year — But a Top Biotech Fund Is Still Buying
fool.com
2025-11-17 11:15:23California-based TCG Crossover Management increased its stake in Centessa Pharmaceuticals by 245,664 shares in the third quarter for an estimated $38.1 million. The transaction value equaled about 0.2% of the fund's 13F reportable assets under management (AUM) at quarter-end.

Why Centessa Pharmaceuticals Stock Crushed the Market Today
fool.com
2025-11-12 18:27:06It's gearing up to take in a flood of fresh capital. This is being effected in a secondary issue of its ADSes.

Centessa Pharmaceuticals Announces Pricing of $250,000,000 Public Offering of American Depositary Shares
globenewswire.com
2025-11-11 20:40:00BOSTON and LONDON, Nov. 11, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today announced the pricing of an underwritten public offering of 11,627,907 American Depositary Shares (“ADSs”), each representing one ordinary share, at a price to the public of $21.50 per ADS. The aggregate gross proceeds to Centessa from this offering are expected to be approximately $250 million, before deducting underwriting discounts and commissions and offering expenses payable by Centessa. All ADSs sold in the offering were offered by Centessa. The offering is expected to close on or about November 14, 2025, subject to customary closing conditions. Centessa has also granted the underwriters a 30-day option to purchase up to an additional 1,744,186 ADSs at the public offering price, less underwriting discounts and commissions.

Centessa Pharmaceuticals Announces Proposed Public Offering of American Depositary Shares
globenewswire.com
2025-11-11 16:00:00BOSTON and LONDON, Nov. 11, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today announced that it has commenced an underwritten public offering of American Depositary Shares (“ADSs”), each representing one ordinary share. All of the ADSs are being offered by Centessa.

Centessa Pharmaceuticals to Participate in Upcoming Investor Conferences
globenewswire.com
2025-11-07 08:00:00BOSTON and LONDON, Nov. 07, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company that aims to discover and develop transformational medicines for patients, today announced that members of its management team will participate in the following investor conferences: Event: Guggenheim 2nd Annual Healthcare Innovation Conference Date: Wednesday, November 12, 2025 Fireside Chat: 10:30 AM ET Event: Jefferies Global Healthcare Conference in London Date: Tuesday, November 18, 2025 Fireside Chat: 2:00 PM GMT/ 9:00 AM ET Event: 37th Annual Piper Sandler Healthcare Conference Date: Tuesday, December 2, 2025 Fireside Chat: 3:00 PM ET Event: 8th Annual Evercore Healthcare Conference Date: Wednesday, December 3, 2025 Fireside Chat: 9:35 AM ET Event: Oppenheimer Movers in Rare Disease Summit Date: Thursday, December 11, 2025 Access to the live webcasts of these events, as well as archived recordings, will be available under the “Events and Publications” tab on the investor relations section of the Centessa Pharmaceuticals website at https://investors.centessa.com/. About Centessa Pharmaceuticals Centessa Pharmaceuticals, plc is a clinical-stage pharmaceutical company with a mission to discover, develop and ultimately deliver medicines that are transformational for patients.

46,665 Shares in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA Purchased by Y Intercept Hong Kong Ltd
defenseworld.net
2025-11-06 03:40:52Y Intercept Hong Kong Ltd purchased a new position in shares of Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ: CNTA) in the undefined quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission. The institutional investor purchased 46,665 shares of the company's stock, valued at approximately $613,000.

Centessa Pharmaceuticals Reports Financial Results for the Third Quarter of 2025 and Provides Update on Potential Best-in-Class Orexin Receptor 2 (OX2R) Agonist Program
globenewswire.com
2025-11-05 07:00:00BOSTON and LONDON, Nov. 05, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today reported financial results for the third quarter ended September 30, 2025 and provided an update on its OX2R agonist program, including Phase 2a data1 from the initial dosing cohorts within the ongoing CRYSTAL-1 study of ORX750 in NT1, NT2 and IH participants, and Phase 1 data2 from the ongoing study of ORX142 in healthy volunteers.

Centessa Pharmaceuticals to Participate in the Morgan Stanley 23rd Annual Global Healthcare Conference
globenewswire.com
2025-09-03 07:00:00BOSTON and LONDON, Sept. 03, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company that aims to discover and develop transformational medicines for patients, today announced that members of its management team will participate in the Morgan Stanley 23rd Annual Global Healthcare Conference in New York, NY.

Centessa Pharmaceuticals Reports Financial Results and Business Highlights for the Second Quarter of 2025
globenewswire.com
2025-08-12 07:00:00Advancing a broad, potential best-in-class orexin receptor 2 (OX2R) agonist franchise, with key data readouts expected this year

Nxera Pharma to Receive US$4.8 Million in Milestone Payments Following Centessa's Initiation of Clinical Development of ORX142, a Novel Orexin Receptor 2 (OX2R) Agonist
globenewswire.com
2025-07-04 03:00:00Tokyo, Japan and Cambridge, UK, 4 July 2025 – Nxera Pharma Co., Ltd. (“Nxera” or “the Company”; TSE 4565) today announces that it will receive US$4.8 million in milestone payments from Centessa Pharmaceuticals pursuant to its research collaboration with Centessa. The milestones were achieved as Centessa initiated clinical development of ORX142, its second novel orexin receptor 2 (OX2R) agonist, following the recent clearance of an Investigational New Drug (IND) application by the US Food and Drug Administration (FDA) for a Phase 1 clinical study of ORX142 in healthy volunteers. (click here).

Centessa Pharmaceuticals (CNTA) Upgraded to Buy: What Does It Mean for the Stock?
zacks.com
2025-06-16 13:01:16Centessa Pharmaceuticals (CNTA) has been upgraded to a Zacks Rank #2 (Buy), reflecting growing optimism about the company's earnings prospects. This might drive the stock higher in the near term.

Centessa Pharmaceuticals Announces Clearance of Investigational New Drug Application (IND) for ORX142, a Novel Orexin Receptor 2 (OX2R) Agonist; Clinical Data in Acutely Sleep-Deprived Healthy Volunteers Planned for this Year
globenewswire.com
2025-06-16 09:00:00BOSTON and LONDON, June 16, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has cleared the IND to initiate a Phase 1 clinical study of ORX142 in healthy volunteers. ORX142 is an investigational, novel, highly potent and selective OX2R agonist being developed for the treatment of select neurological and neurodegenerative disorders. ORX142 is the second drug candidate from the Company's multi-asset orexin franchise.
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Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ:CNTA) Receives Consensus Recommendation of “Buy” from Analysts
defenseworld.net
2025-12-13 01:16:58Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ: CNTA - Get Free Report) has been assigned an average recommendation of "Buy" from the thirteen analysts that are currently covering the firm, MarketBeat Ratings reports. One equities research analyst has rated the stock with a sell rating, ten have assigned a buy rating and two have assigned a strong

Centessa Pharmaceuticals Announces CEO Transition as Company Advances Strategy to Extend Orexin Leadership into Multiple Neuroscience Indications
globenewswire.com
2025-12-11 07:00:00Mario Alberto Accardi PhD, President and founder of Centessa's Orexin Program, appointed Chief Executive Officer and member of the Board of Directors Mario Alberto Accardi PhD, President and founder of Centessa's Orexin Program, appointed Chief Executive Officer and member of the Board of Directors

What One Fund's Sale of Centessa Stock Signals About the Fast-Rising Biotech Company
fool.com
2025-11-29 13:48:38San Francisco-based 5AM Venture Management sold 150,000 CNTA shares in the third quarter. Despite the sale, the stock's sharp rally last quarter led the fund's net position value in CNTA to increase by $5.6 million.

Campbell & CO Investment Adviser LLC Acquires New Position in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA
defenseworld.net
2025-11-18 03:53:03Campbell and CO Investment Adviser LLC bought a new position in shares of Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ: CNTA) during the second quarter, according to its most recent filing with the Securities and Exchange Commission. The institutional investor bought 16,619 shares of the company's stock, valued at approximately $218,000. Other hedge funds

Centessa Stock Has Surged 77% Over the Past Year — But a Top Biotech Fund Is Still Buying
fool.com
2025-11-17 11:15:23California-based TCG Crossover Management increased its stake in Centessa Pharmaceuticals by 245,664 shares in the third quarter for an estimated $38.1 million. The transaction value equaled about 0.2% of the fund's 13F reportable assets under management (AUM) at quarter-end.

Why Centessa Pharmaceuticals Stock Crushed the Market Today
fool.com
2025-11-12 18:27:06It's gearing up to take in a flood of fresh capital. This is being effected in a secondary issue of its ADSes.

Centessa Pharmaceuticals Announces Pricing of $250,000,000 Public Offering of American Depositary Shares
globenewswire.com
2025-11-11 20:40:00BOSTON and LONDON, Nov. 11, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today announced the pricing of an underwritten public offering of 11,627,907 American Depositary Shares (“ADSs”), each representing one ordinary share, at a price to the public of $21.50 per ADS. The aggregate gross proceeds to Centessa from this offering are expected to be approximately $250 million, before deducting underwriting discounts and commissions and offering expenses payable by Centessa. All ADSs sold in the offering were offered by Centessa. The offering is expected to close on or about November 14, 2025, subject to customary closing conditions. Centessa has also granted the underwriters a 30-day option to purchase up to an additional 1,744,186 ADSs at the public offering price, less underwriting discounts and commissions.

Centessa Pharmaceuticals Announces Proposed Public Offering of American Depositary Shares
globenewswire.com
2025-11-11 16:00:00BOSTON and LONDON, Nov. 11, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today announced that it has commenced an underwritten public offering of American Depositary Shares (“ADSs”), each representing one ordinary share. All of the ADSs are being offered by Centessa.

Centessa Pharmaceuticals to Participate in Upcoming Investor Conferences
globenewswire.com
2025-11-07 08:00:00BOSTON and LONDON, Nov. 07, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company that aims to discover and develop transformational medicines for patients, today announced that members of its management team will participate in the following investor conferences: Event: Guggenheim 2nd Annual Healthcare Innovation Conference Date: Wednesday, November 12, 2025 Fireside Chat: 10:30 AM ET Event: Jefferies Global Healthcare Conference in London Date: Tuesday, November 18, 2025 Fireside Chat: 2:00 PM GMT/ 9:00 AM ET Event: 37th Annual Piper Sandler Healthcare Conference Date: Tuesday, December 2, 2025 Fireside Chat: 3:00 PM ET Event: 8th Annual Evercore Healthcare Conference Date: Wednesday, December 3, 2025 Fireside Chat: 9:35 AM ET Event: Oppenheimer Movers in Rare Disease Summit Date: Thursday, December 11, 2025 Access to the live webcasts of these events, as well as archived recordings, will be available under the “Events and Publications” tab on the investor relations section of the Centessa Pharmaceuticals website at https://investors.centessa.com/. About Centessa Pharmaceuticals Centessa Pharmaceuticals, plc is a clinical-stage pharmaceutical company with a mission to discover, develop and ultimately deliver medicines that are transformational for patients.

46,665 Shares in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA Purchased by Y Intercept Hong Kong Ltd
defenseworld.net
2025-11-06 03:40:52Y Intercept Hong Kong Ltd purchased a new position in shares of Centessa Pharmaceuticals PLC Sponsored ADR (NASDAQ: CNTA) in the undefined quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission. The institutional investor purchased 46,665 shares of the company's stock, valued at approximately $613,000.

Centessa Pharmaceuticals Reports Financial Results for the Third Quarter of 2025 and Provides Update on Potential Best-in-Class Orexin Receptor 2 (OX2R) Agonist Program
globenewswire.com
2025-11-05 07:00:00BOSTON and LONDON, Nov. 05, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today reported financial results for the third quarter ended September 30, 2025 and provided an update on its OX2R agonist program, including Phase 2a data1 from the initial dosing cohorts within the ongoing CRYSTAL-1 study of ORX750 in NT1, NT2 and IH participants, and Phase 1 data2 from the ongoing study of ORX142 in healthy volunteers.

Centessa Pharmaceuticals to Participate in the Morgan Stanley 23rd Annual Global Healthcare Conference
globenewswire.com
2025-09-03 07:00:00BOSTON and LONDON, Sept. 03, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company that aims to discover and develop transformational medicines for patients, today announced that members of its management team will participate in the Morgan Stanley 23rd Annual Global Healthcare Conference in New York, NY.

Centessa Pharmaceuticals Reports Financial Results and Business Highlights for the Second Quarter of 2025
globenewswire.com
2025-08-12 07:00:00Advancing a broad, potential best-in-class orexin receptor 2 (OX2R) agonist franchise, with key data readouts expected this year

Nxera Pharma to Receive US$4.8 Million in Milestone Payments Following Centessa's Initiation of Clinical Development of ORX142, a Novel Orexin Receptor 2 (OX2R) Agonist
globenewswire.com
2025-07-04 03:00:00Tokyo, Japan and Cambridge, UK, 4 July 2025 – Nxera Pharma Co., Ltd. (“Nxera” or “the Company”; TSE 4565) today announces that it will receive US$4.8 million in milestone payments from Centessa Pharmaceuticals pursuant to its research collaboration with Centessa. The milestones were achieved as Centessa initiated clinical development of ORX142, its second novel orexin receptor 2 (OX2R) agonist, following the recent clearance of an Investigational New Drug (IND) application by the US Food and Drug Administration (FDA) for a Phase 1 clinical study of ORX142 in healthy volunteers. (click here).

Centessa Pharmaceuticals (CNTA) Upgraded to Buy: What Does It Mean for the Stock?
zacks.com
2025-06-16 13:01:16Centessa Pharmaceuticals (CNTA) has been upgraded to a Zacks Rank #2 (Buy), reflecting growing optimism about the company's earnings prospects. This might drive the stock higher in the near term.

Centessa Pharmaceuticals Announces Clearance of Investigational New Drug Application (IND) for ORX142, a Novel Orexin Receptor 2 (OX2R) Agonist; Clinical Data in Acutely Sleep-Deprived Healthy Volunteers Planned for this Year
globenewswire.com
2025-06-16 09:00:00BOSTON and LONDON, June 16, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (Nasdaq: CNTA), a clinical-stage pharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has cleared the IND to initiate a Phase 1 clinical study of ORX142 in healthy volunteers. ORX142 is an investigational, novel, highly potent and selective OX2R agonist being developed for the treatment of select neurological and neurodegenerative disorders. ORX142 is the second drug candidate from the Company's multi-asset orexin franchise.










